Research assistent Julius-Maximilians-University Würzburg, Bayern, Germany
Introduction: The activation of both the humoral and adaptive immune system is crucial in cancer therapy. Protein or peptide based anticancer vaccines frequently require the co-delivery of an immunostimulatory adjuvant to enhance antigen presentation and stimulate a robust immune response. Modular polymer-based nanocarrier platforms provide a versatile strategy for vaccine delivery, enabling tailored formulations and personalized therapy. Site-specific modification of vaccine constructs via selective and efficient click chemistry with peptides, proteins, or small molecules enables improved stability, targeting, and immunogenicity. [1], [2], [3]
Learning Objectives:
Application of bioorthogonal click-chemistry strategies to enable multivalent surface modification of nanogels
Performing chemical modifications of nanobodies and antigens using self-immolative click linkers.
Analysis and validation of receptor-mediated cellular uptake of targeted nanogel–vaccine conjugates.
