Skip to main content
CRS 2026 Annual Meeting & Exposition Main banner

Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Osteogenic Effects of Human Breast Milk–Derived Extracellular Vesicles Mediated by BMP2/MAPK Signaling

Dong-ha Kim – Postdoc, Gyeongkuk National University; Bum-Joon Koo – master student, Gyeongkuk National University; Do-Kyun Kim – Associate Professor, Jeonbuk National University; Young-Eun Cho – Associate Professor, Gyeongkuk National University

    Poster Presenter(s)

  • Jaehee Kwon, MSc

    PhD Candidate
    Gyeongkuk National University, Republic of Korea

Introduction:

Extracellular vesicles (EVs) are nano-sized vesicles (30–150 nm) present in mammalian body fluids, including breast milk, blood, urine, and saliva (1). Surrounded by a lipid bilayer, EVs transport bioactive molecules such as proteins, lipids, DNA, and miRNAs, thereby mediating intercellular communication and regulating diverse biological processes (1). Human breast milk-derived extracellular vesicles (HMEVs) contribute to immune regulation, tissue regeneration, and inflammation control (2); however, their role in bone metabolism remains unclear. This study aimed to evaluate the effects of HMEVs on osteoblast differentiation, mineralization, and underlying osteogenic mechanisms.

Learning Objectives:

  • Understand the role of human breast milk-derived extracellular vesicles in bone metabolism.
  • Explain how BMP2 and MAPK signaling pathways mediate osteoblast differentiation.
  • Evaluate the potential of HMEVs as a novel therapeutic approach for osteoporosis.