Imaging aided strategy for improved transdermal patch biopharmaceutical performance

Michał Dufke – student, Medical University of Gdansk; Malgorzata Sznitowska – professor, Pharmaceutical Technology, Medical University of Gdansk

Poster Presenter(s)

BM

Barbara Mikolaszek, n/a

PhD
Medical University og Gdansk
Gdansk, Pomorskie, Poland

Introduction:

The diffusivity of pressure-sensitive adhesive (PSA) matrix is considered as a crucial parameter for the transdermal delivery system (TDS) performance. While incorporating excipients into the polymer matrix is a conventional strategy for modifying active pharmaceutical ingredient (API) release kinetics and skin permeation, this approach is often limited by complex excipient-PSA-drug interactions and effects physicochemical stability or mechanical properties (peel adhesion or tack) [1,2]. The present study evaluates matrix surface microstructure as a formulation parameter to modulate the in vitro and in vivo biopharmaceutical performance of transdermal patch.

Learning Objectives:

...list features affecting drug release from the TDS.
...list parameters defining drug release from the TDS.
... define most effective way to improve TDS performance.