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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Characterizing Exparel® through an Innovative Dissolution Testing Method

Matthias Wacker – Professor, KU Leuven; Wei Wu – Associate Professor, National University of Singapore; Carin Siow – Senior Application Scientist, Roquette Asia Pacific Pte Ltd; Bing Xun Tan – CTS Lab Manager, Roquette Asia Pacific Pte Ltd

    Poster Presenter(s)

  • JL

    Jeslyn Low

    Graduate Student
    National University of Singapore, Singapore

Introduction:

Dialysis-based dissolution studies are commonly employed to characterize the drug release from long-acting formulations, simulating drug diffusion across semi-permeable barriers. (1) However, conventional dialysis methods often face limitations, such as membrane clogging, which compromise accuracy and reproducibility. (2) To address these challenges, the Dispersion Releaser (DR) – a system designed for testing nano-formulations with enhanced membrane transport and improved reproducibility – was employed to characterize the release behaviour of Exparel®, a liposomal bupivacaine formulation.

Learning Objectives:

  • Recognize conventional dialysis limits, including membrane clogging that reduces accuracy and reproducibility
  • Evaluate DR's ability to reproducibly characterize liposomal drug release under biorelevant condition
  • Correlate particle size changes with drug release behavior in Exparel® across storage conditions.