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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Tumor Microenvironment Responsive R848-Loaded Yolk-shall Nanoparticles for enhanced colon cancer therapy

Qiang Yang – PhD student, Southwest University; Jiachen Li – PhD candidate, University Medical Center Groningen University of Groningen; Jie Gao – PhD student, University Medical Center Groningen University of Groningen; Gésinda Geertsema-Doornbusch – Technician, University Medical Center Groningen University of Groningen; Kiyan Musaie – PhD student, University Medical Center Groningen University of Groningen; Helder Santos – Full Professor, University Medical Center Groningen University of Groningen; Mohammad-Ali Shahbazi – Assistant Professor, University Medical Center Groningen University of Groningen

    Poster Presenter(s)

  • YZ

    Yuewen Zhu, n/a

    PhD candidate
    University Medical Center Groningen University of Groningen
    Lanzhou, China (People's Republic)

Introduction:

Colon cancer remains a prevalent clinical challenge. Herein, we developed a tumor microenvironment (TME)-responsive[2] yolk–shell[1] nanoparticle platform integrating photothermal therapy[3]. The system consists of a polydopamine (PDA) yolk and MnO₂/CuO shells, further stabilized with DSPE-PEG2000 to form PDA@(MnO₂/CuO)-DSPE-PEG2000 YSNs (P@MC-DP). Resiquimod (R848) was efficiently loaded to obtain PR@MC-DP YSNs. In the glutathione-rich TME, shell decomposition triggers R848 release and intracellular Fenton reactions[4], while the PDA core enables near-infrared (NIR)-induced photothermal tumor ablation.

Learning Objectives:

  • Upon completion, participant will be able to understand the theoretical basis of nanosystems designed based on TME
  • Upon completion, participant will be able to understand the systematic advantages of yolk-shell nanoparticles.