Student Universidad Autonoma de Baja California Tijuana, Baja California, Mexico
Introduction: Ciprofloxacin loaded chitosan nanoparticles (CNPs) have inhibited growth of P. aeruginosa and methicillin resistant S. aureus (MRSA). Potential applications include aerosol nasal spray for pulmonary infections, dermal patches, gel-like formulations for burn treatment, etc. Given the rising of multiresistant microbes, special interest is set in localized and targeted therapy, such as the integration of nanoformulations into medical devices.The objective of this research is to determine the release capacity of ciprofloxacin from chitosan nanoparticles incorporated into a dressing used for wounds and carry out its characterization, as well as antimicrobial and cytotoxicity evaluation.
Learning Objectives:
Design, synthesize and characterize ciprofloxacin-chitosan nanoparticles for integration into wound dressings
Incorporate nanoparticles into dressings and evaluate drug release and stability
Assess antimicrobial activity and cytotoxicity of nanoparticle-coated dressings.
