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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Boron cluster assembled nanosystems as boron agents for BNCT

Takeshi Nagasaki – Professor, Osaka Metropolitan University; Yu Sanada – Assistant professor, Kyoto University; Minoru Suzuki – Professor, Kyoto University; Keita Yamana – Assistant professor, Hiroshima University; Atsushi Ikeda – Professor, Hiroshima University
Introduction:

With minimal invasiveness, BNCT is considered a promising modality for cancer treatment. BNCT selectively eradicates cancer cells through lethal DNA damage induced by highly cytotoxic α-particles and lithium nuclei generated from the nuclear reaction between neutrons and boron-10. Efficient intracellular delivery of boron agents is essential to maximize therapeutic efficacy. Although clinically used agents such as boronophenylalanine (BPA) and sodium borocaptate (BSH) are available, limitations in tumor selectivity and cellular accumulation remain [1]. Here, we developed a self-assembled system incorporating hydrophobic carborane to improve boron delivery efficiency.

Learning Objectives:

  • Participants can describe design principles of boron cluster–assembled nanosystems for enhancing BNCT efficacy.
  • Participants will be able to explain how nanoparticle morphology influences therapeutic efficacy in BNCT.
  • Participants will be able to design morphology-controlled boron delivery systems to improve BNCT outcomes.