Introduction: Therapeutic drug monitoring (TDM) of antibiotics requires reliable determination of drug concentrations in biological fluids to ensure optimal dosing and minimize toxicity. Conventional methods, such as LC–MS and immunoassays are accurate but not suited for simple, point-of-care testing. Surface-enhanced Raman spectroscopy (SERS) enables molecularly specific, label-free detection and offers a promising route towards reliable TDM sensors. Here we present, flame aerosol nanomanufacturing used to engineer plasmonic Ag–SiO₂ nanoaggregates for reproducible antibiotic sensing in biological fluids.
Learning Objectives:
Understand the application of SERS-based sensors for therapeutic drug monitoring of antibiotics.
Gain insight into how engineered Ag–SiO₂ nanostructures enable reproducible
