Hybrid nanoparticle system loaded with novel anti-biofilm compound for the treatment of skin wound infections
Patrick Rijn – Professor, BBT, University of Groningen; Helder Santos – Professor, BBT, University of Groningen; Wouter Hinrichs – Professor, Pharmaceutical Technology and Biopharmacy, University of Groningen; Peter Nibbering – Chief Scientific Officer, HHV Biotech
PhD University of Groningen Medical Centre (UMCG) Groningen, Netherlands
Introduction: Biofilm-associated infections pose a significant threat to healthcare systems due to treatment failure, which is associated with an increase in costs and patient suffering.1 Conventional antimicrobials are limited by poor biofilm penetration, enzymatic degradation, and development of antibiotic-tolerant and even resistant subpopulations.2 This study presents a novel strategy to deliver NDX, a naturally derived antibiofilm compound using hybrid lipid-polymer nanoparticles (LPNs). The LPNs are engineered to overcome NDX’s hydrophobicity, low aqueous solubility, and in vivo instability.
Learning Objectives:
Demonstrate hybrid LPNs enhance stability and provide sustained release of hydrophobic drugs.
Evaluate antibacterial and antibiofilm efficacy of NDX-loaded LPNs against AMR pathogens;
Assess biocompatibility of NDX-loaded LPNs using ex-vivo pigskin model.
