Senior Lecturer in Pharmaceutics University of Strathclyde Glasgow, England, United Kingdom
Introduction: Dosage form options for chemotherapy-induced nausea and vomiting (CINV) therapy currently include oral tablets and intravenous injections, which have significant limitations that can impact treatment success (1). Microarray patches (MAPs) are promising for transdermal delivery due to their painless and fast-acting approach (2) and have not yet been developed at clinical stage for this application. Material choice impacts the effectiveness of MAPs, with polymers offering high drug loading capacity and biocompatibility (3). Here, we propose the delivery of a clinically relevant antiemetic in different MAP formulations to provide a suitable alternative to current CINV treatment options.
Learning Objectives:
Understand the impact of material choices in the performance of polymeric MAP formulations.
Assess different polymeric formulations in film and MAP dosage forms.
Investigate the potential of dissolving MAPs for transdermal delivery of antiemetics.
