Development and Characterisation of auto-regulatory nanosystem for the delivery of Glycosylated Insulin
Sarjana Raikwar – Associate Professor, Pharmacy, Gyan Ganga Institute of Technology and Sciences; Suresh Vyas – Retired Professor, Department of Pharmaceutical Sciences, Dr. Harisingh Gour University
NA Gyan Ganga Institute of Technology and Sciences JABALPUR, Madhya Pradesh, India
Introduction: Diabetes and its associate secondary complications are the major cause of mortality worldwide affecting 463 million people globally in 2019 and projected to reach 700 million by 2045. Despite a century passed since the discovery of Insulin, adequate maintenance of euglycemia and prevention of complications are yet to be achieved. We developed an auto regulatory nano system based on Concanavalin A and Glycosylated Insulin that forms a depot in vivo. The system is based on affinity regulated competitive release of glycosylated insulin, maintaining euglycemia for days upon single administration, reducing complications and thus improving the quality of life of patients
Learning Objectives:
Understanding the affinity replacement of G-Insulin with glucose using Con A encapsulated within nanosystem
Developing a nanosystem that will help diabetics by preventing them from diabetes related secondary complications
